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Abstract #2655

Preferential utilization of acetate in human meningiomas

Omkar B Ijare1, David Baskin1, Suzanne Powell2, and Kumar Pichumani1
1Neurosurgery, Houston Methodist Hospital and Research Institute, Houston, TX, United States, 2Pathology and Genomic Medicine, Houston Methodist Hospital and Research Institute, Houston, TX, United States

Synopsis

Meningiomas are the most frequently reported central nervous system (CNS) tumors, accounting for 37% of all CNS tumors. Atypical meningiomas (WHO grade-II) show increased cellular proliferation and recurrence. Currently, no chemotherapy is part of the standard of care for meningiomas, and surgery followed by radiotherapy is the mainstay of treatment. Metabolism is the key to many biological processes including tumorigenesis. Unravelling metabolic phenotypes of various histological subtypes of meningiomas will identify new targets for the therapeutic intervention of these tumors. Here, we investigate the in vivo metabolism of [U-13C]glucose and [1,2-13C]acetate in meningioma patients using 13C NMR based isotopomer analysis.

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