Tissue Sodium Concentration Quantifies Cell Response after Radiation Therapy with Stereotactic Radiosurgery
Anne Adlung1, Sherif A Mohamed2,3, Michaela AU Hoesl1, Frank A Giordano4,5, Eva Neumaier Probst2, Lothar R Schad1, and Arne M Ruder4,6
1Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, 2Department of Neuroradiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, 3Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany, 4Department of Radiation Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, 5Department of Radiation Oncology, University Hospital Bonn, Bonn, Germany, 6Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany
We investigated TSC within Gross Tumor Volume (GTV), and surrounding tissue and healthy tissue (HR). 12 patients with a total of 14 GTV was included. 23Na MRI were acquired at three different time-points (2days pre-, 5days post-, 40days post-SRS). TSC was measured within GTV, HR and isodose-areas between 2 and 18Gy at all time-points. Results show changes in TSC within GTV shortly after SRS and subsequent TSC recovery. TSC was higher within higher isodose-areas showing a correlation of radiation exposure and TSC. Findings suggest that TSC might be able to quantify cell response to radiation of tumorous and healthy tissue.
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