Abstract #2661

Tissue Sodium Concentration Quantifies Cell Response after Radiation Therapy with Stereotactic Radiosurgery

Anne Adlung¹, Sherif A Mohamed^2,3, Michaela AU Hoesl¹, Frank A Giordano^4,5, Eva Neumaier Probst², Lothar R Schad¹, and Arne M Ruder^4,6

¹Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ²Department of Neuroradiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ³Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany, ⁴Department of Radiation Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ⁵Department of Radiation Oncology, University Hospital Bonn, Bonn, Germany, ⁶Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany

Synopsis

We investigated TSC within Gross Tumor Volume (GTV), and surrounding tissue and healthy tissue (HR). 12 patients with a total of 14 GTV was included. ²³Na MRI were acquired at three different time-points (2days pre-, 5days post-, 40days post-SRS). TSC was measured within GTV, HR and isodose-areas between 2 and 18Gy at all time-points. Results show changes in TSC within GTV shortly after SRS and subsequent TSC recovery. TSC was higher within higher isodose-areas showing a correlation of radiation exposure and TSC. Findings suggest that TSC might be able to quantify cell response to radiation of tumorous and healthy tissue.

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