Open Science Initiative for Perfusion Imaging (OSIPI): A community-led, open-source code library for analysis of DCE/DSC-MRI
Petra J van Houdt1, Sudarshan Ragunathan2, Michael Berks3, Zaki Ahmed4, Lucy Kershaw5, Oliver Gurney-Champion6, Sirisha Tadimalla7, Jesper Kallehauge8, Jonathan Arvidsson9, Ben Dickie10, Simon Lévy11, Laura Bell12, Steven Sourbron13, and Michael Jonathan Thrippleton14
1Department of Radiation Oncology, the Netherlands Cancer Institute, Amsterdam, Netherlands, 2Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 3Quantitative Biomedical Imaging Laboratory, Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom, 4Radiology, Mayo Clinic, Rochester, MN, United States, 5Edinburgh Imaging and Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom, 6Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, 7Institute of Medical Physics, The University of Sydney, Sydney, Australia, 8Department of Oncology, Aarhus University, Aarhus, Denmark, 9Institute of Clinical Sciences, Department of Radiation Sciences, The University of Gothenburg, Gothenburg, Sweden, 10Manchester Academic Health Science Centre, Division of Informatics, Imaging, and Data Science, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom, 11Institute of Radiology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 12Clinical Imaging, Genentech, Inc, South San Francisco, CA, United States, 13Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, 14Edinburgh Imaging and Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom
A lack of validated, open-source code reduces the reliability of perfusion MRI, resulting in duplicate development. To address this problem, the Open Science Initiative for Perfusion Imaging (OSIPI) established a taskforce to collect, validate and harmonise such code. To date, 74 code contributions have been collected, with 14 of these tested. Source code and tests are published in an open-access repository. The OSIPI DCE/DSC-MRI code collection constitutes a valuable resource for researchers, and will ultimately be developed into a standardised, community-driven open-source code library.
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