Abstract #2691

Open Science Initiative for Perfusion Imaging (OSIPI): A community-led, open-source code library for analysis of DCE/DSC-MRI

Petra J van Houdt¹, Sudarshan Ragunathan², Michael Berks³, Zaki Ahmed⁴, Lucy Kershaw⁵, Oliver Gurney-Champion⁶, Sirisha Tadimalla⁷, Jesper Kallehauge⁸, Jonathan Arvidsson⁹, Ben Dickie¹⁰, Simon Lévy¹¹, Laura Bell¹², Steven Sourbron¹³, and Michael Jonathan Thrippleton¹⁴

¹Department of Radiation Oncology, the Netherlands Cancer Institute, Amsterdam, Netherlands, ²Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, ³Quantitative Biomedical Imaging Laboratory, Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom, ⁴Radiology, Mayo Clinic, Rochester, MN, United States, ⁵Edinburgh Imaging and Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom, ⁶Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, ⁷Institute of Medical Physics, The University of Sydney, Sydney, Australia, ⁸Department of Oncology, Aarhus University, Aarhus, Denmark, ⁹Institute of Clinical Sciences, Department of Radiation Sciences, The University of Gothenburg, Gothenburg, Sweden, ¹⁰Manchester Academic Health Science Centre, Division of Informatics, Imaging, and Data Science, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom, ¹¹Institute of Radiology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ¹²Clinical Imaging, Genentech, Inc, South San Francisco, CA, United States, ¹³Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, ¹⁴Edinburgh Imaging and Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom

Synopsis

A lack of validated, open-source code reduces the reliability of perfusion MRI, resulting in duplicate development. To address this problem, the Open Science Initiative for Perfusion Imaging (OSIPI) established a taskforce to collect, validate and harmonise such code. To date, 74 code contributions have been collected, with 14 of these tested. Source code and tests are published in an open-access repository. The OSIPI DCE/DSC-MRI code collection constitutes a valuable resource for researchers, and will ultimately be developed into a standardised, community-driven open-source code library.

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