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Abstract #2693

A model for fat-suppressed variable flip angle T1-mapping and dynamic contrast enhanced MRI

Myrte Wennen1,2, Manon Moll3, Tim Marcus2, Joost Kuijer2, Leo Heunks1, Christina Lavini2, Gustav Strijkers2, Aart Nederveen2, and Oliver Gurney-Champion2
1Intensive Care, Amsterdam UMC, Amsterdam, Netherlands, 2Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, 3University of Twente, Enschede, Netherlands


Although fat suppression can substantially improve image quality, the pulses corrupt the steady-state in a spoiled GRE sequence used for DCE and T1-relaxometry. Consequently, the conventional signal equations for quantifying tissue properties (T1, Ktrans, etc) do not hold. We have now included the effect of fat-suppression pulses in the signal equation that forms the basis for T1-relaxometry and DCE modelling. We have validated our equation with T1-mapping in a phantom and show its performance in healthy subjects and patients. Our equation enables accurate T1-mapping and pharmakinetic modelling for sequences that use fat suppression, including GRASP.

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