Abstract #2727

Fabrication of an Anthropomorphic, In-Vitro Liver Flow Phantom for Use in Motion-Robust MRI Sequence Validation Experiments

James Rice^1,2, Ruiqi Geng^2,3, Diego Hernando^2,3,4,5, and Alejandro Roldan-Alzate^1,2

¹Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁴Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁵Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

A major limitation of standard diffusion-weighted imaging (DWI) in the various organs, including the liver, is the presence of artifacts, bias, and poor reproducibility resulting from physiologic cardiovascular-induced motion. Recent efforts to develop motion-robust DWI sequences show promise, but there is an important unmet need for highly controlled validation in motion phantoms. This study presents the fabrication of an anthropomorphic liver flow phantom that can produce compressive motion in the liver to generate and control artifact seen in DW images. This phantom may enable improved validation of motion-robust DWI and other motion-robust applications.

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