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Abstract #2742

Qualitative and Quantitative Imaging Phenotypes can Predict CDKN2A/B Homozygous Deletion Status in IDH-mutant Astrocytomas

Yae Won Park1, Ki Sung Park2, Sung Soo Ahn1, Inho Park1, and Se Hoon Kim1
1Yonsei University College of Medicine, Seoul, Korea, Republic of, 2Pohang University of Science and Technology, Seoul, Korea, Republic of


CDKN2A/B homozygous deletion is a key molecular marker in the 2021 WHO classification of IDH-mutant astrocytomas; presence of CDKN2A/B homozygous deletion results in a grade of 4. On multivariable analysis, infiltrative pattern, larger tumor volume, and higher 95th percentile of nCBV were independent predictors of CDKN2A/B homozygous deletion. The infiltrative pattern and larger volume may be reflected from the increased tumor cell proliferation, whereas the higher 95th percentile of nCBV may reflect the increased angiogenesis due to CDKN2A/B homozygous deletion.

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