CDKN2A/B homozygous deletion is a key molecular marker in the 2021 WHO classification of IDH-mutant astrocytomas; presence of CDKN2A/B homozygous deletion results in a grade of 4. On multivariable analysis, infiltrative pattern, larger tumor volume, and higher 95th percentile of nCBV were independent predictors of CDKN2A/B homozygous deletion. The infiltrative pattern and larger volume may be reflected from the increased tumor cell proliferation, whereas the higher 95th percentile of nCBV may reflect the increased angiogenesis due to CDKN2A/B homozygous deletion.
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