MRI Monitoring of Therapeutic Efficacy of Novel Heme targeting drugs in Non-small cell lung cancer (NSCLC) Orthotopic Tumors in Mice
Li Liu1, Donghan Yang1, Janaka Wansapura1, Guiyang Hao1, Ralph P. Mason1, and Li Zhang2
1Radiology, The University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Biological Sciences, University of Texas at Dallas, Richardson, TX, United States
The goal was to evaluate the activity of two novel heme targeting drugs in Non-Small Cell Lung Cancer models using multi-modality imaging. We found that the novel heme targeting drugs CycT (cyclopamine tartrate) and HSP2 (heme-sequestering peptide 2) were effective in suppressing NSCLC lung tumor growth as assessed by multimodality imaging and confirmed by pathology/histology. MRI detected the H1395 and H1299 orthotopic xenografts and was correlated with PET studies and histology.
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