Magnetic resonance mapping with calculation of extracellular volume fraction allows for a reliable assessment of liver cirrhosis severity
Narine Mesropyan1, Patrick A. Kupczyk1, Leona Dold2, Michael Praktiknjo2,3, Johannes Chang2,3, Alexander Isaak1, Christoph Endler1, Dmitrij Kravchenko1, Leon Bischoff1, Alois M. Sprinkart1, Claus C. Pieper1, Daniel Kuetting 1, Christian Jansen2,3, Ulrike I. Attenberger1, and Julian A. Luetkens1
1Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany, 2Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany, 3Center for Cirrhosis and Portal Hypertension Bonn (CCB), University Hospital Bonn, Bonn, Germany
Assessment of disease severity in patients with liver cirrhosis is of great clinical importance and allows outcome prediction and overall mortality risk estimation. In the present study, we investigated the diagnostic utility of MRI-derived extracellular volume fraction (ECV) for the assessment of liver cirrhosis severity and differentiation between different Child-Pugh classes. Our study results demonstrated a high diagnostic performance of ECV for the assessment of liver cirrhosis severity and offer a reliable discrimination between different Child-Pugh classes. ECV might be a new quantitative marker for the assessment of liver cirrhosis severity, which can be calculated from quantitative liver MRI.
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