A Cloud-based MR Spectroscopy Tool for Basis Set Simulation
Steve C.N. Hui1,2, Muhammad G. Saleh3, Helge J. Zöllner1,2, Georg Oeltzschner1,2, Hongli Fan1,4, Yue Li5, Yulu Song1,2, Hangyi Jiang1, Jamie Near6,7, Susumu Mori1,2, Hanzhang Lu1,2, and Richard A.E. Edden1,2
1Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 4Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 5AnatomyWorks, LLC, Ellicott City, MD, United States, 6Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 7Sunnybrook Research Institute, Toronto, ON, Canada
MRSCloud is an online-based spectral simulation tool for brain metabolites. Up to 32 metabolites can be simulated to generate a basis set for linear combination modeling. The 1D projection method, coherence pathway filters and pre-calculation of propagators have been implemented for density-matrix simulations to run on a high-performance cloud server. Results indicated simulations were comparable with FID-A and difference between simulations of spatial points (21x21/41x41/101x101) were small. It allows community users to generate vendor, sequence, editing experimental-specific basis sets that are appropriate for their studies.
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