Abstract #2773

A Cloud-based MR Spectroscopy Tool for Basis Set Simulation

Steve C.N. Hui^1,2, Muhammad G. Saleh³, Helge J. Zöllner^1,2, Georg Oeltzschner^1,2, Hongli Fan^1,4, Yue Li⁵, Yulu Song^1,2, Hangyi Jiang¹, Jamie Near^6,7, Susumu Mori^1,2, Hanzhang Lu^1,2, and Richard A.E. Edden^1,2

¹Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ⁴Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵AnatomyWorks, LLC, Ellicott City, MD, United States, ⁶Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁷Sunnybrook Research Institute, Toronto, ON, Canada

Synopsis

MRSCloud is an online-based spectral simulation tool for brain metabolites. Up to 32 metabolites can be simulated to generate a basis set for linear combination modeling. The 1D projection method, coherence pathway filters and pre-calculation of propagators have been implemented for density-matrix simulations to run on a high-performance cloud server. Results indicated simulations were comparable with FID-A and difference between simulations of spatial points (21x21/41x41/101x101) were small. It allows community users to generate vendor, sequence, editing experimental-specific basis sets that are appropriate for their studies.

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