Validation in Deep Learning for enhancement of diffusion Magnetic Resonance Imaging results usually sticks to conventional image similarity metrics. Despite those results, further research on synthetic data may result in discordance with the real one. In this paper we have compared 61 real gradient directions against 61 quasi-identical synthetic gradient directions, obtained by subsampling the real ones, for the assessment of the differences between chronic and episodic migraine patients. Even with high image comparison metrics, differences in t-test are not compelling. For that reason, we do not recommend synthetic images for clinical use.
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