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Abstract #2825

Assessing Skeletal Muscle Metabolism with PCr, NAD+NADH, and pH measurement with Dynamic 31P MRS at 7T

Sai Krishna Merugumala1, Huijun Liao1, Wufan Zhao1, and Alexander P Lin1
1Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States


A supine leg extension ergometer targeting the quadriceps femoris was built to be MR compatible and dynamic 31P-MR spectroscopy was acquired during an exercise challenge in a 7 Tesla MRI system. With the higher field strength, PCr and PCr recovery could be measured with a high confidence of fit without the need for additional smoothing and filtering steps. The increased spectral dispersion at 7T shows sufficient separation between the NAD+NADH resonance in addition to increased SNR. pH estimation in the active skeletal muscle was also performed.

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