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Abstract #2835

In vivo characterization of preclinical hereditary RCC models by Electron Paramagnetic Resonance and Magnetic Resonance Imaging

Yuki Shibata1, Daniel R. Crooks1, Shun Kishimoto2, Murali C. Krishna2, and W. Marston Linehan1
1Urologic Oncology Branch, National Institute of Health, Bethesda, MD, United States, 2Radiation Biology Branch, National Institute of Health, Bethesda, MD, United States


Human renal cell carcinomas (RCC) have a variety of pathologies and are known to have alterations in cellular metabolism, although many aspects remain unknown. Fumarate hydratase (FH)-deficient tumors exhibit a shift to aerobic glycolytic system due to several factors including loss and mutation of mitochondrial DNA. We investigated the partial pressure of oxygen, vascular permeability, and blood perfusion in FH-deficient UOK262 xenografts and a type 1 papillary RCC xenograft using EPRI and DCE-MRI. Despite low oxygen consumption rates in vitro, UOK262 xenografts showed a modest median pO2 and increased hypoxic fraction as compared to a type 1 papillary RCC xenografts.

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