Abstract #2835

In vivo characterization of preclinical hereditary RCC models by Electron Paramagnetic Resonance and Magnetic Resonance Imaging

Yuki Shibata¹, Daniel R. Crooks¹, Shun Kishimoto², Murali C. Krishna², and W. Marston Linehan¹

¹Urologic Oncology Branch, National Institute of Health, Bethesda, MD, United States, ²Radiation Biology Branch, National Institute of Health, Bethesda, MD, United States

Synopsis

Human renal cell carcinomas (RCC) have a variety of pathologies and are known to have alterations in cellular metabolism, although many aspects remain unknown. Fumarate hydratase (FH)-deficient tumors exhibit a shift to aerobic glycolytic system due to several factors including loss and mutation of mitochondrial DNA. We investigated the partial pressure of oxygen, vascular permeability, and blood perfusion in FH-deficient UOK262 xenografts and a type 1 papillary RCC xenograft using EPRI and DCE-MRI. Despite low oxygen consumption rates in vitro, UOK262 xenografts showed a modest median pO₂and increased hypoxic fraction as compared to a type 1 papillary RCC xenografts.

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