Human renal cell carcinomas (RCC) have a variety of pathologies and are known to have alterations in cellular metabolism, although many aspects remain unknown. Fumarate hydratase (FH)-deficient tumors exhibit a shift to aerobic glycolytic system due to several factors including loss and mutation of mitochondrial DNA. We investigated the partial pressure of oxygen, vascular permeability, and blood perfusion in FH-deficient UOK262 xenografts and a type 1 papillary RCC xenograft using EPRI and DCE-MRI. Despite low oxygen consumption rates in vitro, UOK262 xenografts showed a modest median pO2 and increased hypoxic fraction as compared to a type 1 papillary RCC xenografts.
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