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Abstract #2846

NODDI-FAST derived parameters are echo-time independent

Maryam H Alsameen1, Zhaoyuan Gong1, Matthew Kiely1, Curtis Triebswetter1, and Mustapha Bouhrara1
1Magnetic Resonance Physics of Aging and Dementia Unit, National Institute on Aging, NIH, Baltimore, MD, United States


In a previous work, we introduced the NODDI-FAST approach to address issues regarding overestimated CSF and neurite density (NDI) fractions in white matter seen with the original NODDI approach. However, in both NODDI-FAST and NODDI signal models, the compartment-specific T2 relaxations are not considered. Therefore, derived parameter estimates, especially NDI, could be dependent on echo time (TE). Here, we show that, as expected, ODI derived values using either NODDI or NODDI-FAST are TE-independent. We also confirm that NDI derived values using NODDI are TE-dependent. More importantly, we show that NDI derived values using NODDI-FAST are TE-independent.

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