Application of a two-pool model of water exchange to myelin water fraction in multiple sclerosis spinal cord
Sharada Balaji1, Irene M. Vavasour2,3, Adam Dvorak1, Poljanka Johnson4, Alex MacKay1,2, and Shannon H. Kolind1,2,3,4
1Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 2Radiology, University of British Columbia, Vancouver, BC, Canada, 3International Collaboration on Repair Discoveries, Vancouver, BC, Canada, 4Medicine, University of British Columbia, Vancouver, BC, Canada
Myelin water fraction (MWF) quantifies myelin content in the central nervous system. MWF analysis typically assumes there is no water exchange between different water pools in tissue during the measurement. Here we investigate the effect of incorporating a two-pool model of exchange in a study of MWF in multiple sclerosis (MS) spinal cord and compare with results from the original algorithm. Including exchange resulted in higher MWF values and myelin water residence times that were correlated with MWF, but maintained the expected relationship in MWF between MS subtypes and controls.
This abstract and the presentation materials are available to members only;
a login is required.