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Abstract #2858

SPION relaxivity at low field strengths with hyperpolarized 129Xe

Nicholas Bryden1, Christian T McHugh1, Michele Kelley1, and Rosa T Branca1
1University of North Carolina Chapel Hill, Chapel Hill, NC, United States


We provide superparamagnetic iron oxide longitudinal relaxivity measurements at both high (11.7 T) and low (0.6 – 2.1 mT) magnetic field strengths, for both 1H and hyperpolarized 129Xe nuclei. These measurements show significant increase in relaxivity at low field for both nuclei. We also provide some preliminary in vivo results for hyperpolarized 129Xe that suggest a depolarization mechanism similar to that of SPIONs from the hemoglobin found in whole blood.

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