Abstract #2872

Calibration-free parallel transmission for improved CSF mobility imaging at 7T

Philipp Ehses¹, Lydiane Hirschler^1,2, Eberhard Daniel Pracht¹, Katerina Deike-Hofmann¹, Vincent Gras³, Franck Mauconduit³, Aurélien Massire⁴, Nicolas Boulant³, Matthias J. P. van Osch², and Tony Stoecker^1,5

¹German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, ²Radiology, Leiden University Medical Center, Leiden, Netherlands, ³University of Paris-Saclay, CEA, CNRS, BAOBAB, NeuroSpin, Gif sur Yvette, France, ⁴Siemens Healthcare SAS, Saint-Denis, France, ⁵Department of Physics and Astronomy, University of Bonn, Bonn, Germany

Synopsis

Better understanding of how the brain cleans itself is of high importance as its failure has been linked to various neurodegenerative diseases. A first step towards elucidating CSF-mediated clearance mechanisms is the measurement of CSF motion in the human brain. In this work, we present an imaging sequence for CSF mobility measurements employing calibration-free parallel transmission. During the imaging session, no pulse calculations or complex B1 shimming procedures are necessary, making this approach feasible for large scale patient studies.

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