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Abstract #2872

Calibration-free parallel transmission for improved CSF mobility imaging at 7T

Philipp Ehses1, Lydiane Hirschler1,2, Eberhard Daniel Pracht1, Katerina Deike-Hofmann1, Vincent Gras3, Franck Mauconduit3, Aurélien Massire4, Nicolas Boulant3, Matthias J. P. van Osch2, and Tony Stoecker1,5
1German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 2Radiology, Leiden University Medical Center, Leiden, Netherlands, 3University of Paris-Saclay, CEA, CNRS, BAOBAB, NeuroSpin, Gif sur Yvette, France, 4Siemens Healthcare SAS, Saint-Denis, France, 5Department of Physics and Astronomy, University of Bonn, Bonn, Germany


Better understanding of how the brain cleans itself is of high importance as its failure has been linked to various neurodegenerative diseases. A first step towards elucidating CSF-mediated clearance mechanisms is the measurement of CSF motion in the human brain. In this work, we present an imaging sequence for CSF mobility measurements employing calibration-free parallel transmission. During the imaging session, no pulse calculations or complex B1 shimming procedures are necessary, making this approach feasible for large scale patient studies.

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