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Abstract #2890

Associations between DCE-MRI parameters and MVD, VEGF and HIF-1α in osteosarcoma based on MRI-histopathological comparison

Huan Ma1, Yao Wang1, Kun Li1, Yingying Ding1, Jialu Li2, and Xiaoyong Zhang3
1Department of Radiology, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China, 2Department of Radiology, HangZhou Medical College Affiliated Lin'An People's Hospital, Hangzhou, Zhejiang Province, China, 3Clinical Science, Philips Healthcare, Chengdu, China, Chengdu, China


Tumor necrosis, angiogenesis and hypoxia are related to therapeutic effect, aggressiveness, metastasis and prognosis for osteosarcoma. In this study, DCE-MRI were matched ROI-to-ROI with histopathological tissues to explore the relationship between the perfusion parameters, including Ktrans, Kep, and Ve in each ROI and TNR, MVD, VEGF and HIF-1α in corresponding histopathological specimens, aiming to offer information about angiogenesis and hypoxia in the microenvironment of osteosarcoma timely and non-invasively. We found the perfusion parameters of DCE-MRI have a moderate sensitivity and specificity to evaluate MVD, VEGF and HIF-1α in the histopathological tissues of osteosarcoma, thereby helping microvessel status and hypoxia evaluating.

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