Abstract #2890

Associations between DCE-MRI parameters and MVD, VEGF and HIF-1α in osteosarcoma based on MRI-histopathological comparison

Huan Ma¹, Yao Wang¹, Kun Li¹, Yingying Ding¹, Jialu Li², and Xiaoyong Zhang³

¹Department of Radiology, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China, ²Department of Radiology, HangZhou Medical College Affiliated Lin'An People's Hospital, Hangzhou, Zhejiang Province, China, ³Clinical Science, Philips Healthcare, Chengdu, China, Chengdu, China

Synopsis

Tumor necrosis, angiogenesis and hypoxia are related to therapeutic effect, aggressiveness, metastasis and prognosis for osteosarcoma. In this study, DCE-MRI were matched ROI-to-ROI with histopathological tissues to explore the relationship between the perfusion parameters, including Ktrans, Kep, and Ve in each ROI and TNR, MVD, VEGF and HIF-1α in corresponding histopathological specimens, aiming to offer information about angiogenesis and hypoxia in the microenvironment of osteosarcoma timely and non-invasively. We found the perfusion parameters of DCE-MRI have a moderate sensitivity and specificity to evaluate MVD, VEGF and HIF-1α in the histopathological tissues of osteosarcoma, thereby helping microvessel status and hypoxia evaluating.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.