Tumor necrosis, angiogenesis and hypoxia are related to therapeutic effect, aggressiveness, metastasis and prognosis for osteosarcoma. In this study, DCE-MRI were matched ROI-to-ROI with histopathological tissues to explore the relationship between the perfusion parameters, including Ktrans, Kep, and Ve in each ROI and TNR, MVD, VEGF and HIF-1α in corresponding histopathological specimens, aiming to offer information about angiogenesis and hypoxia in the microenvironment of osteosarcoma timely and non-invasively. We found the perfusion parameters of DCE-MRI have a moderate sensitivity and specificity to evaluate MVD, VEGF and HIF-1α in the histopathological tissues of osteosarcoma, thereby helping microvessel status and hypoxia evaluating.
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