Phosphorous spectra of healthy spleen are useful for studies of splenic malignancies and benign causes of splenomegaly. The main challenge is the relatively small size of the normal spleen and the large distance between human spleen and surface coil. The purpose of this study was to investigate whether it is possible to acquire phosphorous spectra of healthy spleen using single-voxel ISIS sequence on a 3T scanner. We demonstrate that the proposed spectroscopy of human spleen is feasible in a clinically acceptable acquisition time and that transmitter excitation profile and chemical shift displacement errors need to be taken into consideration
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