Robust measurements of current-induced magnetic fields in the human brain by EPI
Fróði Gregersen1,2,3, Cihan Göksu2,4, Hasan Eroğlu1,2, Zhentao Zuo3,5,6, Axel Thielscher1,2, and Lars Hanson1,2
1Section for Magnetic Resonance, DTU Health Tech, Technical University of Denmark, Kgs. Lyngby, Denmark, 2Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark, 3Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China, 4High-Field Magnetic Resonance Center, Max-Planck-Institute for Biological Cybernetics, Tübingen, Germany, 5State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 6Center for Excellence in Brain and Science and Intelligence Technology, Chinese Academy of Sciences, Beijing, China
Magnetic resonance current density imaging (MRCDI) can measure the magnetic fields created in the human brain from currents injected via surface electrodes. Previous methods have demonstrated high sensitivity sufficient for low current strengths (~1 mA). However, they have also proven susceptible to physiological noise. Here we increase the temporal resolution of the method and thereby the robustness to physiological noise by using echo-planar imaging (EPI) for the acquisition. We show that the method produces reliable magnetic field measurements with an average sensitivity of 52 pT for a 2 minutes scan with 3 mm isotropic resolution.
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