Abstract #2964

Brain Dynamic Functional Connectivity are linked with Attention-Deficit/Hyperactivity Disorder Related Cognitive and Behavioral Dimensions

Lekai Luo¹, Lizhou Chen¹, Qian Li¹, Ning He², Yuanyuan Li², Wanfang You¹, Yuxia Wang¹, Yaxuan Wang¹, John A. Sweeney^1,3, Lanting Guo², Qiyong Gong¹, and Fei Li¹

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, ²Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, China, ³Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, United States

Synopsis

Sparse canonical correlation analysis (sCCA) was used to delineate multivariate relationship between dynamic functional connectivity (dFC) and behavior or cognition scores in a cohort of children with and without Attention-Deficit/Hyperactivity Disorder (ADHD). We identified four distinct patterns of dFC, each corresponded to a specific dimension of behavior (inattention/hyperactivity, somatization) or cognitive function (inhibition and flexibility, fluency and memory). Altered dFC within the default mode network (DMN) and between DMN and sensorimotor network (SMN) were common to all dimensions.

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