Brain Dynamic Functional Connectivity are linked with Attention-Deficit/Hyperactivity Disorder Related Cognitive and Behavioral Dimensions
Lekai Luo1, Lizhou Chen1, Qian Li1, Ning He2, Yuanyuan Li2, Wanfang You1, Yuxia Wang1, Yaxuan Wang1, John A. Sweeney1,3, Lanting Guo2, Qiyong Gong1, and Fei Li1
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, China, 3Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, United States
Sparse canonical correlation analysis (sCCA) was used to delineate multivariate relationship between dynamic functional connectivity (dFC) and behavior or cognition scores in a cohort of children with and without Attention-Deficit/Hyperactivity Disorder (ADHD). We identified four distinct patterns of dFC, each corresponded to a specific dimension of behavior (inattention/hyperactivity, somatization) or cognitive function (inhibition and flexibility, fluency and memory). Altered dFC within the default mode network (DMN) and between DMN and sensorimotor network (SMN) were common to all dimensions.
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