The high signal intensity on T2-weighted images in terminal zones (TZ) mainly associated with lower maturational degree. We hypothesized that the stiffness in these regions may be different from typical developing children without TZ. Virtual stiffness of brain can be measured safely with virtual magnetic resonance elastography (vMRE). Therefore, this study tried to use vMRE to investigate differences between children with and without TZ. Results demonstrated that virtual stiffness of TZ was lower than controls, while higher than periventricular leukomalacia. These suggest that vMRE may provide additional information for evaluating brain maturation and injury.