Abstract #3044

The value of diffusion kurtosis imaging in detecting delayed brain development of premature infants

Xin Zhao¹, Chunxiang Zhang¹, Bohao Zhang², Jiayue Yan³, Jinxia Guo⁴, Kaiyu Wang⁴, Zitao Zhu⁵, and Xiaoan Zhang⁶

¹Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ²Henan Key Laboratory of Child Brain Injury, Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ³McGill university Montreal, Zhengzhou, China, ⁴GE Healthcare, MR Research China, Beijing, China, ⁵Wuhan University, Wuhan, China, ⁶The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China

Synopsis

Preterm infants are at high risk of adverse neurodevelopmental outcome. Therefore, it is necessary to find a tool to detect brain developmental abnormalities earlier. Diffusion kurtosis imaging (DKI) is considered as a more accurate technology based on a kurtosis model accounting for the variation of Gaussian distribution caused by complex cellular environments in compare with diffusion tensor imaging. The mean kurtosis (MK) in posterior limbs of the internal capsule (PLIC), anterior limb of internal capsule (ALIC), the mean diffusion (MD) in parietal white matter (PWM) were found with good diagnostic performance for abnormal brain microstructural change.

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