The value of diffusion kurtosis imaging in detecting delayed brain development of premature infants
Xin Zhao1, Chunxiang Zhang1, Bohao Zhang2, Jiayue Yan3, Jinxia Guo4, Kaiyu Wang4, Zitao Zhu5, and Xiaoan Zhang6
1Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2Henan Key Laboratory of Child Brain Injury, Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 3McGill university Montreal, Zhengzhou, China, 4GE Healthcare, MR Research China, Beijing, China, 5Wuhan University, Wuhan, China, 6The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Preterm infants are at high risk of adverse neurodevelopmental outcome. Therefore, it is necessary to find a tool to detect brain developmental abnormalities earlier. Diffusion kurtosis imaging (DKI) is considered as a more accurate technology based on a kurtosis model accounting for the variation of Gaussian distribution caused by complex cellular environments in compare with diffusion tensor imaging. The mean kurtosis (MK) in posterior limbs of the internal capsule (PLIC), anterior limb of internal capsule (ALIC), the mean diffusion (MD) in parietal white matter (PWM) were found with good diagnostic performance for abnormal brain microstructural change.
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