Thalamic plasticity plays an important role in the functional remodeling in brains with glioma. This study investigated the frequency-specific functional alteration of the thalami in the context of gliomas with discrete wavelet transformation and wavelet-energy. Brains with glioma in the left hemisphere featured with amplified inter-thalamus energy deviation for BOLD signals at 15.63-250mHz irrespective of the malignant grades, as compared with healthy controls. Similar analysis revealed no energy changes for the right brain gliomas. These findings suggest a differential thalamic plasticity that is specific to the tumor laterality, and may leverage innovation in the treatment of glioma involving neuromodulation.
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