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Abstract #3054

Thalamic Plasticity in Brains with Glioma Investigated with Discrete Wavelet Transformation Analysis of Resting-stateĀ BOLD Fluctuations

Siqi Cai1,2, Zhifeng Shi3, Chunxiang Jiang1,2, Shihui Zhou1,2, and Lijuan Zhang*1
1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2University of Chinese Academy of Sciences, Beijing, China, 3Huashan Hospital of Fudan University, Shanghai, China


Thalamic plasticity plays an important role in the functional remodeling in brains with glioma. This study investigated the frequency-specific functional alteration of the thalami in the context of gliomas with discrete wavelet transformation and wavelet-energy. Brains with glioma in the left hemisphere featured with amplified inter-thalamus energy deviation for BOLD signals at 15.63-250mHz irrespective of the malignant grades, as compared with healthy controls. Similar analysis revealed no energy changes for the right brain gliomas. These findings suggest a differential thalamic plasticity that is specific to the tumor laterality, and may leverage innovation in the treatment of glioma involving neuromodulation.

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