In this study, we aimed to explore the deeper molecular mechanism of radiomics features, and uncover new GBM prognostic biomarker. We extracted radiomics features out of 57 patients with MRI data obtained from TCIA database and corresponding clinical and transcription information from TCGA database. WGCNA revealed that the radiomics features are correlated with numerous cancer-associated biological processes, including regulation of vasculature development and so on. HMGA2 as the hub gene was screened by Cytoscape software. There was significant difference in survival analysis between the high and low expression groups, indicating that HMGA2 may be a new prognostic biomarker for GBM.