Obesity is a global health condition that leads to many kinds of diseases. Bone marrow fat (BMF) is considered as the third largest fat depot in human body. It has been proved that BMF is closely related with energy storage, bone metabolism, endocrine function and hematologic diseases. To understand the relation between BMF and weight loss is crucial within obesity related diseases scenario. Few studies have been published focusing on BMF variation so far. In this study, chemical shift encoding-based water-fat MRI (CSE-MRI) was employed to demonstrate the positive correlation between BMF and parts of the weight loss indicators.