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Abstract #3101

Preliminary assessment of 3D APT-weighted combined with diffusion weighted imaging in characterization of bone and soft tissue tumors

Ying Li1, Jingliang Cheng1, Wenhua Zhang1, and Liangjie Lin2
1The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2Philips Healthcare, Beijing, 100102, China, Beijing, China


Amide proton transfer weighted imaging (APTWI) is a noninvasive emerging molecular MRI technique based on chemical exchange saturation transfer (CEST) between amide protons of proteins and polypeptides and free water protons. This work investigated and evaluated the ability of APT parameter in distinguishing benign from malignant bone and soft tissue tumors. Results indicated that APTWI combined with diffusion weighted imaging showed a significantly improved differentiation between benign and malignant tumors.

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