Amide proton transfer weighted imaging (APTWI) is a noninvasive emerging molecular MRI technique based on chemical exchange saturation transfer (CEST) between amide protons of proteins and polypeptides and free water protons. This work investigated and evaluated the ability of APT parameter in distinguishing benign from malignant bone and soft tissue tumors. Results indicated that APTWI combined with diffusion weighted imaging showed a significantly improved differentiation between benign and malignant tumors.
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