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Abstract #3114

Changes of brain function in patients with type 2 diabetes by different analysis methods: A new coordinate based meta-analysis of neuroimaging

Zeyang Li1, Teng Ma1, Lin-Feng Yan1, and Guangbin Cui1
1Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi’an 710038, Shaanxi, China, Xi’an, China


Neuroimaging meta-analysis have identified abnormal neural activity alterations involved in type 2 diabetes mellitus (T2DM) patients, but there is no consistency and heterogeneity analysis between different brain imaging processing strategies. For the indicators obtained from varied post-processing methods reflect different neurophysiological and pathological characteristics, we further conducted a coordinated-based meta-analysis (CBMA) for two categories of neuroimaging literature grouped by similar data processing indicators. Compared to healthy controls, T2DM patients showed a significantly decreased brain activity in the right rolandic operculum, right supramarginal gyrus and right postcentral gyrus, providing a new non-invasive biomarker for T2DM neuropathy.

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