Abstract #3116

MRS study on the correlation between frontal GABA+/Glx ratio and abnormal cognitive function in patients with narcolepsy

Yanan Gao¹, Yanting Liu¹, Sihui Zhao¹, Hui Steve², Mikkelsen Mark², Edden A.E. Richard ², Chen Zhang³, and Bing Yu⁴

¹China Medical University, shenyang, China, ²Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA F. M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA, Baltimore, MD, United States, ³MR Scientific Marketing, Siemens Healthineers, BeiJing, China, ⁴China Medical University, Shenyang, China

Synopsis

A series of studies have suggested the cognitive deficits in patients with narcolepsy. The aim of the current study is to explore the correlation between abnormal GABA+/Glx ratio in sleep state and abnormal cognitive function in patients with narcolepsy using Hadamard Encoding and Reconstruction of Mega-Edited Spectroscopy (HERMES) method. This study demonstrate that the ratio of GABA+/Glx in prefrontal lobe of narcolepsy patients during N2 sleep stage were higher than that of normal control group, which may be related to their abnormal cognitive functions.

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