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Abstract #3120

Altered brain white matter connectom underlie affective disorders after mild traumatic brain injury at the acute stage

Wenjing Huang1, Jing Zhang1, Wanjun Hu1, Pengfei Zhang1, Jun Wang1, and Shaoyu Wang2
1Lanzhou University Second Hospital, Lanzhou, China, 2MR Scientific Marketing, Siemens Healthineers, ShangHai, China


Mild traumatic brain injury (mTBI) is not a static event, but a progressive injury. The neuroanatomical alterations of mTBI at the acute stage can be an initial step of damage leading to cognitive and emotional deficit. The potential mechanisms conferring these deficits are poorly understood. In this study, we employed graph theory to explore alterations of white matter connectome and to study their relationship with neuropsychological examinations. We found disrupted topologic manner of the brain’s structural connectome, and the changes of right middle occipital gyrus explain depressive symptoms in the acute phase of mTBI due to white matter network alterations.

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