Mild traumatic brain injury (mTBI) is not a static event, but a progressive injury. The neuroanatomical alterations of mTBI at the acute stage can be an initial step of damage leading to cognitive and emotional deficit. The potential mechanisms conferring these deficits are poorly understood. In this study, we employed graph theory to explore alterations of white matter connectome and to study their relationship with neuropsychological examinations. We found disrupted topologic manner of the brain’s structural connectome, and the changes of right middle occipital gyrus explain depressive symptoms in the acute phase of mTBI due to white matter network alterations.