Abstract #3125

Cerebellar iron accumulation in idiopathic cervical dystonia evaluating by quantitative susceptibility mapping

Hongxia Li¹, Ming Zhang², Hongjiang Wei², and Yiwen Wu¹

¹Department of Neurology & Institute of Neurology, Ruijin Hospital, affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

Synopsis

We found increased susceptibility in patients compared with HCs that primarily involved cerebellar structures . The result of 2D-flatmap visualization showed that the involved subregions of iron accumulation were in the right Crus Ⅱ and right lobule Ⅶb. Interestingly, no significant differences in QSM value of basal ganglia, thalamus, or motor cortex were observed between ICD patients and HCs. Moreover, there was no significant difference between groups regarding the GMV in the cerebellum. Of consistent findings with standard structural MRI technique highlights the potential of probing tissue iron across the cerebellum with QSM as a disease biomarker

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