Abstract #3128

Changes in serial DWI MRI imaging during radiation therapy can predict treatment response in patients with head and neck cancer

Yuvnik Trada^1,2, Paul Keall², Michael Jameson³, Daniel Moses^4,5, Peter Lin^6,7, Phillip Clap^5,8, Lois Holloway^8,9, Myo Min^10,11, Dion Forstner³, Allan Fowler⁹, and Mark Lee^5,9

¹Radiation Oncology, Calvary Mater Newcastle, Waratah, Australia, ²The University of Sydney, Sydney, Australia, ³GenesisCare St Vincents Hospital, Sydney, Australia, ⁴Department of Medical Imaging, Prince of Wales Hospital, Sydney, Australia, ⁵University of New South Wales, Sydney, Australia, ⁶Department of Nuclear Medicine and PET, Sydney, Australia, ⁷Western Sydney University, Sydney, Australia, ⁸Ingham Institute of Applied Medical Research, Liverpool, Australia, ⁹Liverpool Hospital, Liverpool, Australia, ¹⁰Sunshine Coast University Hospital, Sunshine Coast, Australia, ¹¹University of Sunshine Coast, Britinya, Australia

Synopsis

In head and cancer there is a need for a predictive biomarker for patients undergoing radiotherapy(RT) to allow personalisation of treatment.55 patients with HNSCC had DWI imaging performed at baseline, during (week 2, 3, 5 and 6) and post RT (1 and 3 months). Absolute and change in primary tumour ADCmean was correlated to local recurrence.Week 3 was the optimal timepoint for mid-treatment response assessment. Change in week 3 ADCmean of <24.4% predicted local recurrence; corresponding 2 year LRFS of 97% vs 42%.Changes in mid-treatment DWI imaging could be utilised in design of future adaptive clinical trials.

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