To predict the treatment response for NPC patients is very important. This study aimed to explore the diagnostic performance of 3D APT imaging on predicting the treatment response of NPC patients. A total of 40 patients and 14 healthy volunteers were identified in this study. Result show that the APT and MT values have good and excellent intra- and inter-observer agreement. It is significant difference for MT values between residual and non-residual group. The result suggests that the pre-treatment MT values can be used to predict treatment response of NPC with chemoradiotherapy, and better than the APT and ADC value.