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Abstract #3143

Evaluation of Endostar and chemoradiotherapy combination efficacy on cervical cancer bydiffusion kurtosis imaging histogram analysis

Lanhui Qin1, Jin-ting Que1, Xin-shu Li1, Wei-hui Xu1, Sheng-lian Wen1, Huiting Zhang2, Fang Wu1, and Jin-yuan Liao1
1First Affiliated Hospital of Guangxi Medical University, Nanning, China, 2MR Scientific Marketing, Siemens Healthcare Ltd, Nanning, China


This study explored the feasibility of whole tumor diffusion kurtosis imaging (DKI) histogram analysis (HA) to assess concurrent chemoradiotherapy (CCRT) combined with Endostar for locally advanced cervical cancer (LACC) before and during treatment. In terms of predicting efficacy, DKI whole tumor HA showed higher sensitivity and specificity, and higher the area under the ROC curve in the CCRT plus Endostar than in the CCRT group. During the treatment of LACC using Endostar, compared with the mean value of ADC, MD, MK and tumor diameter, DKI whole tumor HA showed excellent potential in monitoring treatment response and predicting early efficacy.

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