This study explored the feasibility of whole tumor diffusion kurtosis imaging (DKI) histogram analysis (HA) to assess concurrent chemoradiotherapy (CCRT) combined with Endostar for locally advanced cervical cancer (LACC) before and during treatment. In terms of predicting efficacy, DKI whole tumor HA showed higher sensitivity and specificity, and higher the area under the ROC curve in the CCRT plus Endostar than in the CCRT group. During the treatment of LACC using Endostar, compared with the mean value of ADC, MD, MK and tumor diameter, DKI whole tumor HA showed excellent potential in monitoring treatment response and predicting early efficacy.
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