This study aims to investigate the feasibility of multi-parametric MRI in distinguishing endometrioma from other ovarian cystic lesions. A total of 50 patients with clinically suspected endometriosis were recruited in the study. Quantitative MRI, including T1, T2 mapping, T2* mapping and CEST, was used. A positive correlation was found between R2* and iron levels in fluid of endometrioma. The AUC of R2*, T1, T2 and MTR_asym were 0.941, 0.996, 0.980 and 0.806, respectively. Therefore, multi-parametric quantitative MRI can be considered an effective method in differentiating endometriomas from various ovarian cystic lesions.
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