Abstract #3157
Developing a comprehensive whole body MR protocol and model generation pipeline for children
Haribalan Kumar*1,2,3, Robby Green*1, Samantha Holdsworth1,4, Daniel Cornfeld1, Paul Condron1, Eryn Kwon1, Taylor Emsden1, Julie Choisne3, Thor Besier3, Justin Fernandez3, Kat Gilbert3, Martyn Nash3, Soroush Safaei3, Gonzalo Maso Talou3, Davidson Taylor1,5,6, Luke Rolfe1,7, Lucy McHugh1,8,9, Graham Hingangaroa Smith10,11,12,13,14,15, Leigh Potter11,16,17,18, Merryn Tawhai3, Kelly Burrowes3, Alys Clark3, Jiantao Shan3, Elias Soltani3, Erana Hogarth1,17, Rinki Murphy4, Josh McGeown1, Laura Carman3, Alan Wang1,3, Maryam Tayebi1,3, Ali Mirjalili4, Grace Cleland-Pottie1,19,20, Mahyar Osanlouy3, Vickie Shim1,3, Jerome Maller2, Reweti Ropiha21, and Graham Wilson1,8
1Mātai Medical Research Institute, Gisborne, New Zealand, 2General Electric Healthcare AUS/NZ, Melbourne, Australia, 3Auckland Bioengineering Institute, Auckland, New Zealand, 4Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, 5Ngāi Tāmanuhiri, Tairāwhiti, New Zealand, 6Rongowhakaata, Tairāwhiti, New Zealand, 7Ngāti Pāhauwera, Hawke's Bay, New Zealand, 8University of Otago, Dunedin, New Zealand, 9Ngāi Tahu, Te Waipounamu, New Zealand, 10Kāti Māmoe, North Otago, New Zealand, 11Mātai Ngā Māngai Māori, Gisborne, New Zealand, 12Te Aitanga a Hauiti, Tairāwhiti, New Zealand, 13Ngāti Apa, Rangitīkei, New Zealand, 14Massey University, Palmerston North, New Zealand, 15Ngāti Kahungunu, Wairarapa, New Zealand, 16Rongomaiwahine, Mahia, New Zealand, 17Ngāti Porou, Tairāwhiti, New Zealand, 18Ngāti Kahungunu, Wairoa, New Zealand, 19University of Cantebury, Christchurch, New Zealand, 20Ngāpuhi, Te Tai Tokerau, New Zealand, 21Turanga Health, Tairāwhiti, New Zealand
Synopsis
Approaches to magnetic resonance (MR) image acquisition and computational modelling often exist in silo. The application of computational modelling to paediatric data is in its infancy. This collaborative study addresses this gap for multiple organ systems. State-of-the art MR imaging sequences were selected and refined to provide imaging data for the creation of subject-specific geometric models. The MR protocol and modelling outputs will underpin a longitudinal paediatric study set in Aotearoa New Zealand, generating normative data in healthy children, and identifying early biomarkers of pathological processes. This will enable the development of new personalised, predictive, and preventative models of care.
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