Abstract #3163

Correlations between functional connectivity and glucose uptake in white matter

Bin Guo^1,2, Fugen Zhou¹, Muwei Li^2,3, Zhaohua Ding^2,4,5, and John C. Gore^2,3,5

¹Image Processing Center, School of Astronautics, Beihang University, Beijing, China, ²Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, ³Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ⁴Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States, ⁵Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

Synopsis

Blood oxygenation-level dependent (BOLD) MRI signals have been reliably detected in white matter (WM) in both task and resting states in numerous studies. However, the relationship between WM BOLD signals and regional metabolism remains to be elucidated. In the present study, we investigated the relationship between resting state functional connectivity and glucose uptake in WM using simultaneous MRI and PET studies of human subjects. We find a significant correlation between these two measurements, suggesting that functional involvement of WM in neural activities was accompanied by an increase in glucose metabolism.

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