Correlations between functional connectivity and glucose uptake in white matter
Bin Guo1,2, Fugen Zhou1, Muwei Li2,3, Zhaohua Ding2,4,5, and John C. Gore2,3,5
1Image Processing Center, School of Astronautics, Beihang University, Beijing, China, 2Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 3Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 4Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States, 5Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States
Blood oxygenation-level dependent (BOLD) MRI signals have been reliably detected in white matter (WM) in both task and resting states in numerous studies. However, the relationship between WM BOLD signals and regional metabolism remains to be elucidated. In the present study, we investigated the relationship between resting state functional connectivity and glucose uptake in WM using simultaneous MRI and PET studies of human subjects. We find a significant correlation between these two measurements, suggesting that functional involvement of WM in neural activities was accompanied by an increase in glucose metabolism.
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