A novel water-fat separated MRF approach was proposed to minimize the known biases introduced by the B1+, B0 and water and fat partial volume. By incorporating the water-fat separation approach in the framework, the dictionary size could be greatly reduced with the known B0 and FF map. Multiple maps of parameters including B1+, B0, FF and T1 and T2* of water and fat can be acquired within 14s for one slice.
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