Abstract #3240

MR microscopy of human embryo at high isotropic spatial resolution

Kazuyuki Makihara¹, Kazuki Kunieda¹, Shigehito Yamada², Katsumi Kose³, and Yasuhiko Terada¹

¹Graduate School of Science and Technology, University of Tsukuba, Tsukuba, Japan, ²Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, ³MRI simulations Inc., Minato-ku, Japan

Synopsis

High-resolution MR microscopy is advantageous for the human embryo study, but had not been realized because of many challenges. In this study, we demonstrated high-resolution MR microscopy of a human embryo specimen with 18 µm isotropic resolution. To achieve the higher spatial resolution than the previous system, we improved the hardware and optimized the pulse sequence. The MR images of the embryo showed detailed anatomical structures and were similar in appearance to the stained images obtained from an embryo specimen at the same developmental stage.

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