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Abstract #3240

MR microscopy of human embryo at high isotropic spatial resolution

Kazuyuki Makihara1, Kazuki Kunieda1, Shigehito Yamada2, Katsumi Kose3, and Yasuhiko Terada1
1Graduate School of Science and Technology, University of Tsukuba, Tsukuba, Japan, 2Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, 3MRI simulations Inc., Minato-ku, Japan


High-resolution MR microscopy is advantageous for the human embryo study, but had not been realized because of many challenges. In this study, we demonstrated high-resolution MR microscopy of a human embryo specimen with 18 µm isotropic resolution. To achieve the higher spatial resolution than the previous system, we improved the hardware and optimized the pulse sequence. The MR images of the embryo showed detailed anatomical structures and were similar in appearance to the stained images obtained from an embryo specimen at the same developmental stage.

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