Abstract #3243

Deuterium metabolism imaging of rat brain at 9.4T using a double-nuclear transceiver

Feng Du^1,2, Jiawen Yuan^1,3, Nan Li^1,2, Chao Zhou^1,2, Qian Wan^1,2, Qikai Qin⁴, Garth J. Thompson⁴, Qiong Ye⁵, Xiaoliang Zhang⁶, Xin Liu^1,2, Hairong Zheng^1,2, and Ye Li^1,2

¹Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province, Shenzhen, China, ³Southern University of Science and Technology, Shenzhen, China, ⁴iHuman Institute, ShanghaiTech University, Shanghai, China, ⁵High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China, ⁶Department of Biomedical Engineering, State University of New York, Buffalo, NY, United States

Synopsis

Deuterium metabolic imaging (DMI) is an emerging technique, which can measure the metabolism in the brain non-invasively after intake of deuterated glucose. In this work, we construct a versatile and dedicated 1H/2H dual-nuclear transceiver for a 9.4T pre-clinical research system. The performance of the transceiver was evaluated by measuring the in vivo 2H spectra data. The metabolites of water, glucose, Glx and lactate after glucose infusion were quantified in healthy and glioma rats using the constructed double-nuclear transceiver.

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