Deuterium metabolism imaging of rat brain at 9.4T using a double-nuclear transceiver
Feng Du1,2, Jiawen Yuan1,3, Nan Li1,2, Chao Zhou1,2, Qian Wan1,2, Qikai Qin4, Garth J. Thompson4, Qiong Ye5, Xiaoliang Zhang6, Xin Liu1,2, Hairong Zheng1,2, and Ye Li1,2
1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province, Shenzhen, China, 3Southern University of Science and Technology, Shenzhen, China, 4iHuman Institute, ShanghaiTech University, Shanghai, China, 5High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China, 6Department of Biomedical Engineering, State University of New York, Buffalo, NY, United States
Deuterium metabolic imaging (DMI) is an emerging technique, which can measure the metabolism in the brain non-invasively after intake of deuterated glucose. In this work, we construct a versatile and dedicated 1H/2H dual-nuclear transceiver for a 9.4T pre-clinical research system. The performance of the transceiver was evaluated by measuring the in vivo 2H spectra data. The metabolites of water, glucose, Glx and lactate after glucose infusion were quantified in healthy and glioma rats using the constructed double-nuclear transceiver.
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