Tau accumulation is associated with fiber-specific white matter degeneration in Alzheimer's disease
Khazar Ahmadi1, Joana B. Pereira1,2, Danielle van Westen1,3, Markus Nilsson4, Nicola Spotorno1, and Oskar Hansson1,5
1Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden, 2Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden, 3Diagnostic Radiology, Lund University, Lund, Sweden, 4Department of Medical Radiation Physics, Lund University, Lund, Sweden, 5Memory Clinic, Skåne University Hospital, Malmö, Sweden
Fixel-based analysis (FBA) enables investigation of micro- and macrostructural damage in white matter (WM) fiber bundles. However, the link between microscopic changes in fiber density (FD) and macroscopic morphological alterations in fiber cross-section (FC) with the pathological hallmarks of Alzheimer’s disease (AD) including regional tau and amyloid-β (Aβ) accumulation has not been explored yet. Here, we show that reduction in FC in the AD continuum is closely connected with tau tangles in contrast to Aβ pathology.
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