Abstract #3264

Tau accumulation is associated with fiber-specific white matter degeneration in Alzheimer's disease

Khazar Ahmadi¹, Joana B. Pereira^1,2, Danielle van Westen^1,3, Markus Nilsson⁴, Nicola Spotorno¹, and Oskar Hansson^1,5

¹Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden, ²Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden, ³Diagnostic Radiology, Lund University, Lund, Sweden, ⁴Department of Medical Radiation Physics, Lund University, Lund, Sweden, ⁵Memory Clinic, Skåne University Hospital, Malmö, Sweden

Synopsis

Fixel-based analysis (FBA) enables investigation of micro- and macrostructural damage in white matter (WM) fiber bundles. However, the link between microscopic changes in fiber density (FD) and macroscopic morphological alterations in fiber cross-section (FC) with the pathological hallmarks of Alzheimer’s disease (AD) including regional tau and amyloid-β (Aβ) accumulation has not been explored yet. Here, we show that reduction in FC in the AD continuum is closely connected with tau tangles in contrast to Aβ pathology.

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