Abstract #3284

Applying the single shell 3-Tissue method to investigate long-term degeneration of the visual system following hemidisconnection surgery

Luis Miguel Lacerda¹, Alki Liasis^2,3, Sian Handley³, Martin Tisdall⁴, Helen Cross⁵, Faraneh Vargha-khadem⁵, and Chris Clark¹

¹Developmental Imaging and Biophysics Section, UCL Great Ormond Street Institute of Child Health, LONDON, United Kingdom, ²Children’s Hospital of Pittsburgh, University of Pittsburgh Medical Centre, Pittsburgh, KS, United States, ³Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, ⁴Neurosurgery, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, ⁵Clinical Neurosciences, UCL Great Ormond Street Institute of Child Health, LONDON, United Kingdom

Synopsis

There is a need to map microstructural changes over long time periods and develop/apply methods that work with legacy data. In this study, we applied the novel single shell 3-Tissue method to data from a cohort of 4 patients who were scanned 20-years following childhood hemidisconnection surgery and presented degeneration of the visual system. We believe this study suggests that diffusion MRI can be used to monitor the integrity of the visual system following hemispherectomy and if extended to larger cohorts and a greater number of time-points, provide a clearer picture of the natural history of visual system degeneration.

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