Abstract #3284
Applying the single shell 3-Tissue method to investigate long-term degeneration of the visual system following hemidisconnection surgery
Luis Miguel Lacerda1, Alki Liasis2,3, Sian Handley3, Martin Tisdall4, Helen Cross5, Faraneh Vargha-khadem5, and Chris Clark1
1Developmental Imaging and Biophysics Section, UCL Great Ormond Street Institute of Child Health, LONDON, United Kingdom, 2Children’s Hospital of Pittsburgh, University of Pittsburgh Medical Centre, Pittsburgh, KS, United States, 3Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, 4Neurosurgery, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, 5Clinical Neurosciences, UCL Great Ormond Street Institute of Child Health, LONDON, United Kingdom
Synopsis
There is a need to map microstructural changes over long time periods and develop/apply methods that work with legacy data. In this study, we applied the novel single shell 3-Tissue method to data from a cohort of 4 patients who were scanned 20-years following childhood hemidisconnection surgery and presented degeneration of the visual system. We believe this study suggests that diffusion MRI can be used to monitor the integrity of the visual system following hemispherectomy and if extended to larger cohorts and a greater number of time-points, provide a clearer picture of the natural history of visual system degeneration.
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