Abstract #3286

Validation of non-invasive MR measurement of feto-placental oxygen saturation in a sheep model of human pregnancy

Dimitra Flouri^1,2, Jack RT Darby³, Stacey L Holman³, Sunthara R Perumal⁴, Sebastien Ourselin¹, Anna L David^5,6, Andrew Melbourne^1,2, and Janna L Morrison³

¹School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, ²Department of Medical Physics & Biomedical Engineering, University College London, London, United Kingdom, ³Early Origins of Adult Health Research Group, University of South Australia, Adelaide, Australia, ⁴Preclinical Imaging and Research Laboratories, South Australian Health and Medical Research Institute, Adelaide, Australia, ⁵Institute for Women's Health, University College London, London, United Kingdom, ⁶NIHR Biomedical Research Center, University College London Hospitals, London, United Kingdom

Synopsis

Abnormal placental development is postulated as one of the leading causes of fetal growth restriction (FGR). Advances in MRI technology enable non-invasive measurement of fetal oxygen saturation, but not all have yet been validated. Due to the invasiveness of tests required, validation in human subjects is not possible. Preclinical models such as pregnant sheep allow invasive methods to validate MRI measurements. Here we show that multi-compartment modelling of non-invasive placental MRI can be used to estimate the oxygen saturation of feto-placental oxygenation in normal sheep pregnancy and pregnancies affected by early gestation onstet FGR.

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