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Abstract #3306

Consistent White Matter Parcellation in Adolescent Brain Cognitive Development (ABCD): A ~10k Harmonized Diffusion MRI Study

Fan Zhang1, Suheyla Cetin-Karayumak1, Steve Pieper1, Yogesh Rathi1, and Lauren J O'Donnell1
1Harvard Medical School, Boston, MA, United States


We present a large-scale harmonized dMRI study where we have performed successful white matter(WM) tractography parcellation across ~10k subjects from the ABCD study. We first assess the effects of data harmonization on WM parcellation, followed by an evaluation of WM parcellation using the entire harmonized dataset. We show that after harmonization, more anatomical tracts are identified and their FA values are closer to the harmonization reference data. We also demonstrate highly successful WM parcellation, where overall 99.9% of tracts(73 per subject) are identified. The parcellated WM tracts, as well as their diffusion measures, will be made available to the public.

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