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Abstract #3321

Functional and structural connectomes of subthalamic nucleus subregions in living humans using 7 Tesla MRI

Maria Guadalupe Garcia Gomar1,2, Kavita Singh1, Simone Cauzzo1,3,4, and Marta Bianciardi1
1Brainstem Imaging Laboratory, Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, 2Escuela Nacional de Estudios Superiores, Juriquilla, Universidad Nacional Autónoma de México, Querétaro, Mexico, 3Sant'Anna School of Advanced Studies, Institute of Life Sciences, Pisa, Italy, 4Research Center E. Piaggi, University of Pisa, Pisa, Italy


The subthalamic nucleus (STh) plays a crucial role in the basal ganglia movement-related circuit and it is involved in movement disorders such as Parkinson’s disease, dystonia, and chorea, among others. Its study in living humans is challenging due to limited resolution and contrast in conventional MRI. Previous work developed an in-vivo atlas of two STh subregions based on their fractional anisotropy properties. With the goal of characterizing their function and connectivity, in the present study, we evaluated the functional and structural connectivity of these STh subregions using 7 Tesla MRI and tested their preferential connectivity towards associative or motor regions.

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