Differential D1 and D2 receptor internalization and recycling induced by amphetamine in vivo: a PET/fMRI study
Hanne D Hansen1,2, Martin Schain2, Helen P Deng1, Joseph B Mandeville1,3, Bruce R Rosen1,3, and Christin Y Sander1,3
1A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 2Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, 3Harvard Medical School, Boston, MA, United States
In this study, we imaged the effect of repeated amphetamine injections over >24h using simultaneous PET/fMRI in non-human primates and demonstrate that both internalization and recycling of receptors take place during this timeframe. We provide novel insight into D1 vs. D2 receptor contributions by using a D1 blocking agent in combination with amphetamine injections. These results shed a new light into the timelines of dopamine receptor subtype adaptations and not only provide a link to existing in vitro results but also a foundation for linking receptor-specific mechanisms to initial stages of psychostimulant drug use and abuse.
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