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Abstract #3358

Age-related differences in white matter tract length assessed via TRACULA

Tyler Robinson1, Paul Chang1, and Jean Chen1
1Rotman Research Institute, Baycrest, Toronto, ON, Canada


We examined differences in median tract length with age across eighteen major white matter tracts in 541 subjects of the Human Connectome Project in Aging. We observed a significant negative age effect on tract length in the forceps minor, left cingulum angular bundle, right superior longitudinal fasciculus parietal, and right uncinate fasciculus. Paradoxically, we also report a significant positive age effect on tract length in the forceps major and right cingulate gyrus. Restricted analyses suggest that these effects are driven by female subjects.

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