Abstract #3361

Initial Clinical Experience with MAGNUS Ultra-High-Performance Gradient Coil for Diffusion Microstructure Imaging of Intracranial Pathology

Robert Shih^1,2, Ante Zhu³, J Kevin DeMarco^1,2, H Douglas Morris^1,2, Maureen Hood^1,2, Nastaren Abad³, Radhika Madhavan³, Luca Marinelli³, Thomas Foo³, and Vincent Ho^1,2

¹Uniformed Services University, Bethesda, MD, United States, ²Walter Reed National Military Medical Center, Bethesda, MD, United States, ³GE Research, Niskayuna, NY, United States

Synopsis

The MAGNUS ultra-high-performance gradient coil delivers simultaneous 200 mT/m and 500 T/m/s performance on each axis, with higher PNS thresholds than whole-body gradient coils, which is particularly useful for diffusion microstructure imaging. Our initial clinical experience with the MAGNUS research scanner has successfully identified white matter abnormalities (? intra-axonal edema) using multi-shell DTI (b_max = 4000 s/mm²) and OGSE (f_max = 100 Hz) in an acute symptomatic mTBI subject. It has also successfully identified differences in intracellular volume fraction using multi-shell multi-frequency OGSE (b_max = 2000 s/mm², f_max = 100 Hz) between a low-grade diffuse astrocytoma and a high-grade glioblastoma.

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