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Abstract #3361

Initial Clinical Experience with MAGNUS Ultra-High-Performance Gradient Coil for Diffusion Microstructure Imaging of Intracranial Pathology

Robert Shih1,2, Ante Zhu3, J Kevin DeMarco1,2, H Douglas Morris1,2, Maureen Hood1,2, Nastaren Abad3, Radhika Madhavan3, Luca Marinelli3, Thomas Foo3, and Vincent Ho1,2
1Uniformed Services University, Bethesda, MD, United States, 2Walter Reed National Military Medical Center, Bethesda, MD, United States, 3GE Research, Niskayuna, NY, United States


The MAGNUS ultra-high-performance gradient coil delivers simultaneous 200 mT/m and 500 T/m/s performance on each axis, with higher PNS thresholds than whole-body gradient coils, which is particularly useful for diffusion microstructure imaging. Our initial clinical experience with the MAGNUS research scanner has successfully identified white matter abnormalities (? intra-axonal edema) using multi-shell DTI (bmax = 4000 s/mm2) and OGSE (fmax = 100 Hz) in an acute symptomatic mTBI subject. It has also successfully identified differences in intracellular volume fraction using multi-shell multi-frequency OGSE (bmax = 2000 s/mm2, fmax = 100 Hz) between a low-grade diffuse astrocytoma and a high-grade glioblastoma.

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