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Abstract #3363

Unique Alterations in the Pattern of Iron Deposition in Deep Gray Matter Relative to White Matter Microstructure in Mild Traumatic Brain Injury

Sohae Chung1, Els Fieremans1, Dmitry S. Novikov1, Prin X. Amorapanth2, Joseph F. Rath2, Steven R. Flanagan2, and Yvonne W. Lui1
1Department of Radiology, NYU Grossman School of Medicine, New York, NY, United States, 2Department of Rehabilitation Medicine, NYU Grossman School of Medicine, New York, NY, United States


Primary and secondary injury are both believed to play important roles in the pathogenesis of disease after mild traumatic brain injury (MTBI). Here we investigate the relationships between white matter microstructure and deep gray matter iron deposition after MTBI, which may shed light on primary WM injuries and potential secondary changes in brain iron. Our results show different patterns of correlation between deep gray matter iron content as measured by QSM and WM microstructure as measured by diffusion MRI in MTBI compared with normal controls.

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