Feasibility of VDP Calculation using 19F Free Breathing Spiral Acquisition with Post-Acquisition Denoising
Sang Hun Chung1, Khoi Minh Huynh1, Yong Chen2, Pew-Thian Yap3, Jennifer L. Goralski4,5,6, Scott H. Donaldson4,5, and Yueh Z. Lee3,4
1Biomedical Engineering, University of North Carolina, Chapel hill, NC, United States, 2Department of Radiology, Case Western Reserve University, Cleveland, OH, United States, 3Department of Radiology and Biomedical Research Imaging Center, University of North Carolina, Chapel hill, NC, United States, 4Division of Pulmonary and Critical Care Medicine, University of North Carolina, Chapel hill, NC, United States, 5Marsico Lung Institute/UNC Cystic Fibrosis Center, University of North Carolina, Chapel hill, NC, United States, 6Division of Pediatric Pulmonology, University of North Carolina, Chapel hill, NC, United States
19F lung ventilation MRI is usually acquired with extended breath holds that limit the acquisition to relatively healthy patients. New denoising methods have the potential to decrease the scan time significantly while achieving comparable SNRs. We compare 19F breath held scans to spiral acquisition based scans performed while free breathing combined with post-acquisition denoising in human subjects at 3T. VDP and SNR were evaluated. The denoised spiral scans yield higher SNRs (29.3 average increase) but overestimated VDPs (8.5% average increase). The differences in VDP were correlated (R-squared 0.74). The approach shows the potential for free-breathing 19F MRI ventilation imaging.
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