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Abstract #3391

Reproducibility of Alkaline Inorganic Phosphate Quantification using 31P-Magnetic Resonance Spectroscopy at 3T 

Alexs A Matias1, Corinna F Serviente1,2, Stephen T Decker1, Muhammet E Erol1, Gaia Giuriato 3, Yann Le Fur4, Rajakumar Nagarajan 5, and Gwenael Layec1,6
1Kinesiology, University of Massachusetts at Amherst, Amherst, MA, United States, 2Center for Health and Human Performance, Institute for Applied Life Sciences, University of Massachusetts at Amherst, Amherst, MA, United States, 3Neuroscience, Biomedicine, and Movement Science, University of Verona, Verona, Italy, 4Centre de Resonance Magnetique Biologique et Medicale, Marseille, France, 5Human Magnetic Resonance Center, Institute for Applied Life Sciences, University of Massachusetts at Amherst, Amherst, MA, United States, 6Institute for Applied Life Sciences, University of Massachusetts at Amherst, Amherst, MA, United States

Synopsis

Alkaline inorganic phosphate (Pialk) is a promising biomarker of mitochondrial content in vivo that is technically challenging to assess at 3T. The absolute and relative reproducibility of Pialk in the quadriceps muscle across two visits were assessed in healthy sedentary-to-moderately active young adults using 31P-MRS at 3T. The results of this study demonstrate an excellent absolute and relative reproducibility of the quantification of Pialk in the quadriceps muscle at 3T provided that the coil is positioned at the mid-thigh.

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